Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 85, Pages 12813-12816Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06356k
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21871254, 21532006]
- DICP [DICP ZZBS201602]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17000000]
Ask authors/readers for more resources
A water promoted asymmetric aldol/lactonization/enolization cascade reaction of alpha-keto acids and alpha-keto esters was developed, affording the first general protocol for the construction of chiral quaternary isotetronic acids with excellent enantioselectivity. Theoretical results indicate that intramolecular ionized enamine intermediates stabilized by water generate zwitterionic transition states in a lower activation energy and higher face selectivity, resulting in high activity and chemo- and enantioselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available