Synthesis, characterization and antioxidant/cytotoxic activity of oxovanadium(IV) complexes of methyliminodiacetic acid and ethylenediaminetetracetic acid

Two oxovanadium(IV) complexes, viz., [VO(Me-IDA)(H2O)(2)] (1) and NaH[VO(EDTA)]center dot 4H(2)O (2) (Me-IDA = methyliminodiacetic acid and EDTA = ethylenediaminetetraacetic acid) have been synthesized and characterized by FT-IR, UV-Vis, mass spectrometry, elemental analysis, magnetic moment and thermal analysis, as well as electrochemical measurements including cyclic voltammetry. Both compounds are monomeric with distorted octahedral geometries. Compound 2 has been structurally characterized by using X-ray crystallography. It shows an octahedral V(O)N2O3 coordination geometry, which exhibits chemically significant hydrogen bonding interactions besides showing coordination polymer formation. Compounds 1 and 2 show an irreversible redox peak around +0.80 V versus Ag/AgCl corresponding to one-electron oxidation of V(IV) to V(V). The free radical scavenging activity of compounds 1 and 2 were done using 2,2-diphenyl- 1-picrylhydrazyl (DPPH). Both compounds have shown encouraging ROS scavenging activities. The cytotoxicity effects of both compounds toward two different tumor cells (HePG2 and MCF-7) have been also studied by MIT assay. The IC50 values obtained, after 48 h incubation at 37 degrees C for HepG2 and MCF-7 cell lines were 74.23 and 42.04 mu g/mL for compound 1 and 65.56 and 48.34 mu g/mL for compound 2, respectively. Conclusively, the present investigation provides preliminary results which suggest that such compounds can be promising alternative antitumor agents. (C) 2017 Elsevier B.V. All rights reserved.