Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1149, Issue -, Pages 874-881Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2017.08.058
Keywords
Organotin; Schiff base; Synthesis; Crystal structure; Biological activity
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Funding
- Hunan Provincial Natural Science Foundation of China [2017JJ3003, 2016JJ4008, 2016JJ5004]
- Open Fund Project of Key Laboratory of Functional Organometallic Materials of Hengyang Normal University [GN16K03]
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Schiff base organotin(IV) complexes C1 similar to C5b have been synthesized via the reaction of the substituted salicylaldehyde-o-aminophenol Schiff base ligands (L1 similar to L3) with the dibenzyltin dichloride, n-butyltin trichloride or dibutyltin oxide, respectively. The complexes have been characterized by IR, UV Vis, 1H NMR, 13C NMR spectra, elemental analysis and the crystal structures have been determined by X-ray diffraction. The anticancer activity of the Schiff base ligand and complexes C1 similar to C5b against five species of cancer cell which are Hela, MCF7, HepG2, Colo205, NCI-H460 were tested respectively, the tests showed that C1 similar to C5b exhibited significant anticancer activity for the cancer cells in comparison with the ligand, and the activity was greater than carboplatin. (C) 2017 Published by Elsevier B.V.
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