Journal
DIABETOLOGIA
Volume 59, Issue 1, Pages 77-86Publisher
SPRINGER
DOI: 10.1007/s00125-015-3780-8
Keywords
Computed tomography; Elderly; Hyperinsulinaemic-euglycaemic clamp; Insulin sensitivity; Magnetic resonance; Maternal obesity; Positron emission tomography; Resistance training; Telomere shortening
Categories
Funding
- EU [278603]
- Academy of Finland
- Finnish Cultural Foundation
- Central and Varsinais-Suomi Regional fund
- Turku University Foundation
- University of Turku
- Turku University Hospital
- Abo Academy University
Ask authors/readers for more resources
Aims/hypothesis Maternal obesity predisposes offspring to adulthood morbidities, including type 2 diabetes. Type 2 diabetes and insulin resistance have been associated with shortened telomere length. First, we aimed to investigate whether or not maternal obesity influences insulin sensitivity and its relationship with leucocyte telomere length (LTL) in elderly women. Second, we tested whether or not resistance exercise training improves insulin sensitivity in elderly frail women. Methods Forty-six elderly women, of whom 20 were frail offspring of lean/normal weight mothers (OLM, BMI <= 26.3 kg/m(2)) and 17 were frail offspring of overweight/obese mothers (OOM, BMI >= 28.1 kg/m(2)), were studied before and after a 4 month resistance training (RT) intervention. Muscle insulin sensitivity of glucose uptake was measured using F-18-fluoro-2-deoxyglucose and positron emission tomography with computed tomography during a hyperinsulinaemic-euglycaemic clamp. Muscle mass and lipid content were measured using magnetic resonance and LTL was measured using real-time PCR. Results The OOM group had lower thigh muscle insulin sensitivity compared with the OLM group (p=0.048) but similar whole body insulin sensitivity. RT improved whole body and skeletal muscle insulin sensitivity in the OOM group only (p=0.004 and p=0.013, respectively), and increased muscle mass in both groups (p<0.01). In addition, in the OOM group, LTL correlated with different thigh muscle groups insulin sensitivity (rho >=-0.53; p <= 0.05). Individuals with shorter LTL showed a higher increase in skeletal muscle insulin sensitivity after training (rho >=-0.61; p <= 0.05). Conclusions/interpretation Maternal obesity and having telomere shortening were associated with insulin resistance in adult offspring. A resistance exercise training programme may reverse this disadvantage among offspring of obese mothers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available