Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 95, Issue 9, Pages 927-934Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-017-1557-x
Keywords
Mucus; Tight junction; Epithelial barrier; Inflammation; IBD
Funding
- Broad Medical Research Program Award at the Crohn's
- Colitis Foundation of America
- NIH [2R01DK074731-04A1]
- Crohn's & Colitis Foundation of America [510260] Funding Source: researchfish
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The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease progression. The loss of barrier integrity increases the translocation of bacterial antigens and stimulates inflammation in the intestinal mucosa, which is the central pathological feature of inflammatory bowel diseases (IBDs). This review focuses on how intestinal mucus and intercellular tight junctions (TJs) act together to maintain the integrity of the colonic barrier and how barrier integrity is dysregulated in IBD.
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