Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 95, Issue 8, Pages 873-886Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-017-1537-1
Keywords
CST1; Breast cancer; Prognostic biomarker
Funding
- National Natural Science Foundation of China [91440106, 81572600]
- Guangdong Natural Science Foundation [S2012010008521]
- Province Planning Project of Guangdong Province, China [2013B021800072]
- Health & Medical Collaborative Innovation Project of Guangzhou City, China [201508020249]
- Young Teachers Funding Project of SunYat-Sen University [13ykpy50]
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Cystatin SN (CST1) belongs to the type 2 cystatin (CST) superfamily, which restricts the proteolytic activities of cysteine proteases. CST1 has been recently considered to be involved in the development of several human cancers. However, the prognostic significance and function of CST1 in breast cancer remains unknown. In the current study, we found that CST1 was generally upregulated in breast cancer at both mRNA and protein level. Furthermore, overall survival (OS) and disease-free survival (DFS) in the low CST1 expression subgroup were significantly superior to the high CST1 expression subgroup (OS, p < 0.001; DFS, p < 0.001), which indicated that CST1 expression level was closely correlated to the survival risk of these patients. Univariate and multivariate analyses demonstrated that CST1 expression was an independent prognostic factor, the same as ER status and nodal status. Next, CST1 overexpression promoted breast cancer cell proliferation, clonogenicity, migration, and invasion abilities. By contrast, knockdown of CST1 attenuated these malignant characteristics in breast cancer cells. Collectively, our study indicates that CST1 cannot only serve as a significant prognostic indicator but also as a potential therapeutic target for breast cancer.
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