Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 95, Issue 9, Pages 995-1003Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-017-1555-z
Keywords
Sepsis; Cathelicidin; Inflammation; Gene expression
Funding
- FAPESP, Sao Paulo Research Foundation [2015/00892-4]
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Antimicrobial peptides possess a myriad of molecular properties including bacterial killing and the regulation of many aspects of innate immunity. Cathelicidins are a group of antimicrobial peptides widely investigated by the scientific community. Many studies have focused on the bactericidal and pro-inflammatory roles of cathelicidins. Because the role of endogenous cathelicidin expression remains obscure in deep-seated systemic infections, we induced sepsis in cathelicidin knockout and wild-type (WT) mice by cecal ligation and puncture, performing transcriptome screening by DNA micro-array in conjunction with other immunologic assays. Cathelicidin-deficient mice showed increased survival compared to WT mice in this established experimental model of polymicrobial sepsis, in association with upregulation of certain key inflammatory response genes. Therefore, cathelicidins can exert both pro- and anti-inflammatory activities depending on the disease and cellular context.
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