4.7 Article

Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 90, Pages 13506-13509

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07131h

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Funding

  1. Research Committee at University of Macau [MYRG2017-00010-ICMS, MYRG2016-00165-ICMS-QRCM]
  2. National Natural Science Foundation of China [21871301]

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The first cucurbit[7]uril functionalized Au nanorods were developed, which allowed noncovalently tailorable surface modification with a targeting ligand and a guest drug molecule, via strong host-guest interactions. The novel nanoplatform exhibited effective, image-guided, targeted chemo-photothermal cancer therapy in vitro and in vivo.

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