CoFe2O4 nanoparticle/ionic liquid modified carbon paste electrode as an amplified sensor for epirubicin analysis as an anticancer drug

A suitable amount of CoFe2O4 nanoparticle (CoFe2O4/NPs) was used for modification of carbon paste electrode in the presence of paraffin oil and 1,3-dipropylimidazolium bromide (1,3-DPIBr) as binders. The modified electrode showed highly catalytic activity for electro-oxidation of epirubicin in biological condition. CoFe2O4 nanoparticle were synthesized by co-precipitation method with diameter of similar to 17.0 nm and characterized with XRD and TEM methods. The chronoamperometry method was used to evaluate diffusion coefficient (D-app) of the epirubicin in phosphate buffer solution pH = 7.0. A calibration curve with sensitivity (0.1426 mu A/mu M) was obtained for epirubicin in the concentration range 0.04-450 mu M at a surface of proposed electrode. Finally, the amplified sensor showed good ability of analysis of epirubicin in injection and serum samples. (C) 2017 Elsevier B.V. All rights reserved.