Journal
JAPANESE DENTAL SCIENCE REVIEW
Volume 55, Issue 1, Pages 139-144Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jdsr.2019.09.006
Keywords
B cells; Sjogren's syndrome; Peripheral blood; Salivary gland; Germinal center; CD27
Categories
Ask authors/readers for more resources
Primary Sjogren's syndrome is a chronic autoimmune disorder of unknown etiology and is characterized by progressive focal lymphocytic infiltration of the lacrimal and salivary glands. Comparison of B cell subsets from the peripheral blood and salivary glands of patients with primary Sjogren's syndrome and those from healthy individuals shows dysregulation and derangement of B cell subsets in both peripheral circulation and in inflamed glandular tissues. This dysregulation is expressed as a decrease in the percentage of CD27+ memory B cells in peripheral blood and an increase in the CD27+ memory B cells in the affected glands. Further, the overall percentage of long-lived autoantibodies-producing plasma cells within the affected glands is increased. In the last two decades, several studies have shown growing evidences that B cells play multiple roles in primary Sjogren's syndrome pathophysiology, and that dysregulation of these cells may actually play a central role in the disease development. (C) 2019 The Author. Published by Elsevier Ltd on behalf of The Japanese Association for Dental Science.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available