Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 237, Issue -, Pages 141-145Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2017.04.075
Keywords
Sarpogrelate hydrochloride; Solubility; Correlation
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2009-0083538]
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In this study, the solubility of sarpogrelate hydrochloride in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, acetone, acetonitrile, and tetrahydrofuran was determined at temperatures ranging from 288.15 K to 308.15 K under atmospheric pressure by using a solid-liquid equilibrium method. The obtained experimental solubility data of sarpogrelate hydrochloride were correlated with the modified Apelblat model, Buchowski-Ksiazczak All model and ideal model. The mole fraction solubility of sarpogrelate hydrochloride in the selected pure solvents increased with the increase in temperature. The maximum mole fraction solubility of sarpogrelate hydrochloride was observed in methanol (1.16 x 10(-2) at 308.15 K), followed by that in ethanol (4.76 x 10(-3) at 308.15 K), 1-propanol (6.98 x 10(-3) at 308.15 K), 1-butanol (4.12 x 10(-4) at 308.15 K), acetonitrile (3.13 x 10(-4) at 308.15 K), acetone (2,75 x 10-(4) at 3 08.1 5 K), 2-propanol (1.86 x 10(-4) at 308.15 K), and tetrahydrofuran (9.92 x 10(-5) at 308.15 K). The correlation and curve fitting results indicated good correlation of the experimental solubility data of sarpogrelate hydrochloride with the modified Apelblat model. Therefore, the experimental solubility and correlation equations established in this study can be useful in the crystallization/purification, preformulation, and formulation stages of sarpogrelate hydrochloride production or testing in laboratories and related industries. (C) 2017 Elsevier B.V. All rights reserved.
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