Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 229, Issue -, Pages 241-245Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2016.12.067
Keywords
Solubility; DHP-5; Solvent mixture; Jouyban-Acree model; van't Hoff equation
Funding
- Deanship of Scientific Research at King Saud University [RG-1435-006]
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Solubility of dihydropyrimidine derivative 4-(4-ethoxyphenyl)-5-(3,4,5 trimethoxybenzoyI)-3,4dihydropyrimidine-2(1H) one (DHP-5), a novel anticancer drug, was experimentally measured in PEG 400 + water binary solvent mixtures over a temperatures range from 298.15 to 318.15 K. Thermodynamic parameters including enthalpy, entropy and Gibbs free energy of the solubility data were calculated using van't Hoff equation. Experimental solubility data was employed to evaluate the relative performance of a number of models including van't Hoff, Apelblat, Yalkowsky and Jouyba-Acree models for their prediction efficacy. The Jouyban-Acree model covering both solvent composition and temperature effects on drug's solubility proved to be superior to the other three models for its prediction accuracy. (C) 2016 Elsevier B.V. All rights reserved.
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