Journal
CRITICAL REVIEWS IN IMMUNOLOGY
Volume 39, Issue 2, Pages 83-92Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2019030225
Keywords
CRAMP; homeostasis; colitis; cancer; microbiota
Categories
Funding
- National Cancer Institute (NCI), National Institutes of Health (NIH) [HHSN261200800001E]
- Intramural Research Program of the NCI, NIH
- National Natural Science Foundation [81873842]
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Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.
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