Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 58, Issue 3, Pages R169-R190Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-16-0082
Keywords
nuclear receptors; breast cancer; circadian clock; metabolism; migration and metastasis
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Funding
- National Breast Cancer Foundation Australia
- UPA Scholarship from University of Sydney
- National Breast Cancer Foundation [PS-16-023] Funding Source: researchfish
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Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determining therapeutic strategies. More recently, there is growing evidence supporting the involvement of multiple nuclear receptors other than the estrogen and progesterone receptors, in the regulation of various processes important to the initiation and progression of breast cancer. We review new insights into the mechanisms of action of NRs made possible by recent advances in genomic technologies and focus on the emerging functional roles of NRs in breast cancer biology, including their involvement in circadian regulation, metabolic reprogramming and breast cancer migration and metastasis.
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