Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 19, Pages 3504-3520Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2017.09.013
Keywords
Protein complex assembly; Polarity proteins; Epithelial cell polarity; Asymmetric cell division; Par complex
Categories
Funding
- Ministry of Science and Technology of the People's Republic of China [2014CB910201, 2014CB910204]
- National Natural Science Foundation of China [31422015, 31670730, 31270778]
- Shanghai Municipal Education Commission [14SG06]
- RGC of Hong Kong [AoE-M09-12]
- Asia Fund for Cancer Research
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Asymmetric local concentration of protein complexes on distinct membrane regions is a fundamental property in numerous biological processes and is a hallmark of cell polarity. Evolutionarily conserved core polarity proteins form specific and dynamic networks to regulate the establishment and maintenance of cell polarity, as well as distinct polarity-driven cellular events. This review focuses on the molecular and structural basis governing regulated formation of several sets of core cell polarity regulatory complexes, as well as their functions in epithelial cell polarization and asymmetric cell division. (C) 2017 Elsevier Ltd. All rights reserved.
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