4.6 Review

Sugar-Lowering Drugs for Type 2 Diabetes Mellitus and Metabolic Syndrome-Review of Classical and New Compounds: Part-I

Journal

PHARMACEUTICALS
Volume 12, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/ph12040152

Keywords

diabetes mellitus; metabolic syndrome; glucose-lowering agents; sugar-lowering oils; phytotherapy

Funding

  1. Portuguese Science and Technology Foundation (FCT/MCT)
  2. European Funds (PRODER/COMPETE) [M-ERA-NET/0004/2015-PAIRED, UID/AGR/04033/2019]
  3. FEDER, under the Partnership Agreement PT2020
  4. Institute of Nanoscience and Nanotechnology under the project ART(2018)

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Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia together with disturbances in the metabolism of carbohydrates, proteins and fat, which in general results from an insulin availability and need imbalance. In a great number of patients, marketed anti-glycemic agents have shown poor effectiveness in maintaining a long-term glycemic control, thus being associated with severe adverse effects and leading to an emerging interest in natural compounds (e.g., essential oils and other secondary plant metabolites, namely, flavonoid-rich compounds) as a novel approach for prevention, management and/or treatment of either non-insulin-dependent diabetes mellitus (T2DM, type 2 DM) and/or Metabolic Syndrome (MS). In this review, some of these promising glucose-lowering agents will be comprehensively discussed.

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