Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 429, Issue 23, Pages 3577-3586Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2017.08.014
Keywords
innate lymphoid cells; metabolism
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Funding
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIAID NIH HHS [R01 AI100874, R01 AI130043] Funding Source: Medline
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Innate lymphoid cells (ILCs) are tissue-resident first responders of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease. In this brief review, we summarize recent studies that demonstrate the ability of ILCs to influence tissue and systemic metabolism, as well as how ILC biology can be regulated by environmental changes in host metabolism. We also highlight studies showing how ILC-intrinsic metabolism influences their activation, proliferation, and homeostasis. Finally, this review discusses the challenges and open questions in the rapidly expanding field of immunometabolism. (C) 2017 Elsevier Ltd. All rights reserved.
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