Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 429, Issue 18, Pages 2747-2751Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2017.06.025
Keywords
adenovirus structure; hexon; protein IX; molecular mold; protein network
Categories
Funding
- National Institutes of Health [R01A1070771, R21A1103692]
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Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX molecules is conserved among different human adenoviruses(HAdVs), but not in non-HAdVs. In this report, we propose a distinct role for the hexon protein as a molecular mold in enabling the formation of such hexagonal protein IX network that has been shown to preserve the stability and infectivity of HAdVs. (C) 2017 Elsevier Ltd. All rights reserved.
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