Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 107, Issue -, Pages 52-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2017.05.002
Keywords
Phosphatase; Connexin 43; Gap junction
Categories
Funding
- National Institutes of Health [HL113640, HL80101]
- American Heart Association [3770030, 12050478, 25860028]
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Sufficient connexin-mediated intercellular coupling is critical to maintain gap junctional communication for proper cardiac function. Alterations in connexin phosphorylation state, particularly dephosphorylation of connexin 43 (Cx43), may impact cell coupling and conduction in disease states. Cx43 dephosphorylation may be carried out by protein phosphatase activity. Here, we present an overview of the key phosphatases known to interact with Cx43 or modulators of Cx43, as well as some possible therapeutic targets to regulate phosphatase activity in the heart. (C) 2017 Published by Elsevier Ltd.
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