Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 110, Issue -, Pages 38-53Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2017.06.011
Keywords
TLR-4 signaling pathway; Aorta; Aorta aneurysms; Treatments
Categories
Funding
- Italian Ministry of Education, University and Research [C26A14BEA4-2014]
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Recent advances in the field of innate immunity have revealed a complex role of innate immune signaling pathways in both tissue homeostasis and disease. Among them, the Toll-like receptor 4 (TLR-4) pathways has been linked to various pathophysiological conditions, such as cardiovascular diseases (CVDs). This has been interrogated by developing multiple laboratory tools that have shown in animal models and clinical conditions, the involvement of the TLR-4 signaling pathway in the pathophysiology of different CVDs, such as atherosclerosis, ischemic heart disease, heart failure, ischemia-reperfusion injury and aorta aneurysm. Among these, aorta aneurysm, a very complex pathological condition with uncertain etiology and fatal complications (i.e. dissection and rupture), has been associated with the occurrence of high risk cardiovascular conditions, including thrombosis and embolism. In this review, we discuss the possible role of TLR-4 signaling pathway in the development of aorta aneurysm, considering the emerging evidence from ongoing investigations. Our message is that emphasizing the role of TLR-4 signaling pathway in aorta aneurysm may serve as a starting point for future studies, leading to a better understanding of the pathophysiological basis and perhaps the effective treatment of this difficult human disease. (C) 2017 Elsevier Ltd. All rights reserved.
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