Reproductive Outcomes in Patients With Intrauterine Adhesions Following Hysteroscopic Adhesiolysis: Experience From the Largest Women's Hospital in China

Study Objective: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs). Design: Retrospective, cross-sectional study (Canadian Task Force classification 11-2). Setting: University tertiary referral center. Patients: Three hundred and fifty-seven patients with mild, moderate, and severe IUAs who underwent hysteroscopic adhesiolysis between January 2012 and December 2015. Interventions: Hysteroscopic adhesiolysis in the outpatient analgesic setting for infertility and IUAs. Measurements and Main Results: Among the 357 patients (135 with mild IUAs, 116 with moderate IUAs, and 106 with severe IUAs) who underwent hysteroscopic adhesiolysis, 334 (93.6%) experienced a completely restored uterine cavity. The reproductive outcomes of 332 women (93%) were followed for an average duration of 27 +/- 9 months, and the overall conception rate after hysteroscopic adhesiolysis was 48.2%, which decreased with increased MA severity (mild, 60.7%; moderate, 53.4%; severe, 25%). The mean time to conception following hysteroscopic adhesiolysis was 9.7 +/- 3.7 months. The miscarriage rate was 9.4%, and the live birth rate was no lower than 85.6%. Eleven patients (7.9%) had postpartum hemorrhage, including 6 (4.3%) due to adherent placenta and 3 (2.1%) due to placenta accreta. Conclusion: Hysteroscopic adhesiolysis is a feasible and effective way to improve fertility in patients with Asherman's syndrome. (C) 2016 AAGL. All rights reserved.