Journal
MATTER
Volume 1, Issue 6, Pages 1669-1680Publisher
CELL PRESS
DOI: 10.1016/j.matt.2019.08.014
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Funding
- National Natural Science Foundation of China [81971771, 81771983, 81750110544, 81750410695, 81851110764, 81650110523]
- Shanghai Science and Technology Commission [16441909300]
- Ministry of Science and Technology of China [2017YFC0909000]
- Innovation Research Plan by the Shanghai Municipal Education Commission [ZXWF082101]
- Shanghai Rising-Star Program [19QA1404800]
- Changjiang Scholars Program
- Chinese Government 1000 Young Talent Plan
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Metabolic analysis features ongoing biological pathways and can be more distal over proteomic/genomic approaches for in vitro diagnostics (IVD). However, point-of-care (POC) metabolic analysis needs designed materials to detect target biomarkers of low concentration in complex biosystems. Herein, we report the construction of a multifunctional platinum nanoreactor intended for POC metabolic analysis for visual detection and mass spectrometry (MS) fingerprinting. Controlled core-shell structured Fe3O4@SiO2@Pt particles were designed for visual detection of metabolic biomarkers, the catalytic mechanism was investigated, and direct laser desorption/ionization MS fingerprinting of the native serum was performed. The nanoreactor platform has been successfully applied to diagnose pancreatic cancer patients as compared with healthy individuals with sensitivity of 84% and specificity of 92%, with a panel of five biomarkers identified. Our work demonstrates a novel platform for IVD initiating application-driven design of POC analysis with tailored characteristics.
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