Journal
LAB ON A CHIP
Volume 19, Issue 23, Pages 3917-3921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9lc00796b
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Funding
- National Research Foundation of Korea [NRF-2018R1D1A1A09084044]
- Kwangwoon University
- Competency Development Program for Industry Specialists of the Korean Ministry of Trade, Industry and Energy (MOTIE) [P0002397]
- Ministry of Health & Welfare (MOHW), Republic of Korea [P0002397] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (similar to 5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device.
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