Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 60, Issue 20, Pages 8620-8630Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.7b01189
Keywords
-
Categories
Funding
- National Science Centre, Poland [2014/13/B/ST5/04510]
- European Union [POIG.02.01.00-12-064/08]
- Ministry of Science and Higher Education of the Republic of Poland
Ask authors/readers for more resources
Human herpesviruses are among the most prevalent pathogens and currently there are no drugs available that could cure diseases induced by them. The most widely utilized antiherpes drugs, acyclovir and its derivatives, have serious limitations, such as low bioavailability and severe side effects. The current paper reports on the synthesis and characterization of cationic dextran derivatives (DEXxDSy) of various molecular weights and various degrees of substitution with ammonium groups, which were tested as antiherpes agents. DEXxDSy, showed high effectiveness against HSV-1 and HSV-2 viruses, as found using a variety of techniques. Importantly, no toxicity was observed for these compounds in the range of active concentrations, demonstrating their potential as antivirals. The mechanism of action of DEX(x)JS(y) was assessed. We hypothesize that they may limit virus transmission, as extensive examination showed that they hamper the interaction between the virus and the cellular attachment receptor.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available