Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 60, Issue 23, Pages 9413-9436Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.6b01026
Keywords
-
Categories
Funding
- MEC (Ministerio de Educacion y Ciencia, Spain)
- MINECO (Ministerio de Economia y Competitividad, Spain)
- GVA (Generalitat Valenciana, Spain)
- Green Molecular S.L. (Paterna, Spain)
- Chromadex Inc. (Irvine, CA, USA)
Ask authors/readers for more resources
Natural polyphenols are organic chemicals which contain phenol units in their structures. They show antitumor properties. However, a key problem is their short half-life and low bioavailability under in vivo conditions. Still, definitively demonstrating the human benefits of isolated polyphenolic compounds (alone or in combination) using modern scientific methodology has proved challenging. The most common discrepancy between experimental and clinical observations is the use of nonphysiologically relevant concentrations of polyphenols in mechanistic studies. Thus, it remains highly controversial how applicable underlying mechanisms are with bioavailable concentrations and biological half-life. The present Perspective analyses proposed antitumor mechanisms, in vivo reported antitumor effects, and possible mechanisms that may explain discrepancies between bioavailability and bioefficacy. Polyphenol metabolism and possible toxic side effects are also considered. Our main, conclusion emphasizes that these natural molecules (and their chemical derivatives) indeed can be very useful, not only as cancer chemopreventive agents but also in oncotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available