Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 89, Issue 10, Pages 1734-1742Publisher
WILEY
DOI: 10.1002/jmv.24838
Keywords
acute respiratory infections (ARI); genotype; group B; human respiratory syncytial virus
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Funding
- Secretaria Nacional de Ciencias, Tecnologia e Innovacion Panama (SENACYT) [CAP10-001]
- Agencia Nacional de Investigacion e Innovacion de Uruguay, (ANII)
- Programa de Desarrollo de las Ciencias Basicas del Uruguay, (PEDECIBA)
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In Panama, human respiratory syncytial virus (HRSV) is responsible of 20-40% of acute respiratory infections in children under 5 years old. Currently, little is known about the genetic variability of HRSV in Central America and the Caribbean. Recently, we reported the genetic variability of HRSV-A, however; no studies on HRSV-B in Panama have been described yet. In this study, 24 sequences of Panamanian HRSV-B, from children (< 5 years) with acute respiratory infections (ARI), collected from July 2008 to November 2012 were analyzed. All sequences share the characteristic 60-nt duplication of the BA strains. Six Panamanian strains grouped with the BA10 genotype and 12 samples clustered together in a separate monophyletic clade with an aLRT support value of 0.92 and an intra-group p-distance less than 0.07. This fulfills the criteria to consider a new genotype in HRSV, which we named BA14 genotype. Another six strains remain unclassified, but closely related to BA9, BA11, or the new BA14 genotypes, according to their genetic p-distance. Different amino acid substitutions in the Panamanian HRSV-B strains were observed, some previously described and others found only on Panamanian strains. This study contributes to the knowledge of the genetic variability and evolution of HRSV in Central America.
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