Journal
CHEMICAL SCIENCE
Volume 10, Issue 44, Pages 10388-10394Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc02961c
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Funding
- Australian Research Council
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis (CMM), University of Queensland
- Queensland node of the Australian National Fabrication Facility
- Chinese Scholarship Council Scholarship
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A bottom-up self-assembly approach is developed for the synthesis of ABC type heterotrimeric nanoparticles, which can be converted into secondary Janus-type silica derivatives. Compared to spherical ones, Janus silica nanoparticles stimulate stronger phagocytosis and transcytosis through intestinal epithelial microfold cells and exhibit higher cargo transport across an in vitro epithelial monolayer model mimicking the human intestinal epithelium.
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