4.6 Article

Self-mineralization and assembly of a bis-silylated Phe-Phe pseudodipeptide to a structured bioorganic-inorganic material

Journal

MATERIALS HORIZONS
Volume 6, Issue 10, Pages 2040-2046

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9mh00580c

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Funding

  1. ANR (Agence Nationale de la Recherche), the French National Research Agency [ANR-16-CE18-0003]
  2. GIS IBISA
  3. ITMO Cancer
  4. Agence Nationale de la Recherche (ANR) [ANR-16-CE18-0003] Funding Source: Agence Nationale de la Recherche (ANR)

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Self-mineralization of a trialkoxysilyl hybrid peptide yields in a single step a nanostructured hybrid material. A bis-silylated pseudodipeptide inspired from the Phe-Phe dipeptide was used to program the assembly by sol-gel polymerization under heterogeneous conditions, in water at pH 1.5 without any structure-directing agent. A mechanism deciphering the hybrid material assembly was proposed thanks to H-1 NMR spectroscopy. First, water-insoluble hybrid building blocks were hydrolysed into their soluble silanol counterparts. Then, these transitional species, thanks to hydrogen bonding and pi-pi stacking, self-assembled in solution. Last, the proximity of the silanol moieties favoured their polycondensation into growing siloxane oligomers, which spontaneously precipitated to produce an ordered hybrid material.

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