Journal
GENES & DISEASES
Volume 6, Issue 4, Pages 342-358Publisher
ELSEVIER
DOI: 10.1016/j.gendis.2019.09.008
Keywords
Chronic inflammation; Chronic wounds; Growth factors; Personalized medicine; Skin; Stem cells; Wound healing
Funding
- National Institutes of Health [CA226303, DE020140]
- U.S. Department of Defense [OR130096]
- Chicago Biomedical Consortium
- Searle Funds at The Chicago Community Trust
- Scoliosis Research Society
- National Key Research and Development Program of China [2016YFC1000803, 2011CB707906]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR000430]
- Summer Research Program of The University of Chicago Pritzker School of Medicine
- Mabel Green Myers Research Endowment Fund
- University of Chicago Orthopaedic Alumni Fund
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With the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient. The most promising potential treatment options rely on stem cell-based therapies. Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function. Clinical approaches involving stem cells could thus be utilized in some cases to improve a body's inhibited healing capacity. We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential. Given the current problems and complications presented by chronic wounds, we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. Copyright (C) 2019, Chongqing Medical University. Production and hosting by Elsevier B.V.
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