4.1 Article Proceedings Paper

CD4+Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

Journal

JOURNAL OF MEDICAL PRIMATOLOGY
Volume 46, Issue 4, Pages 154-157

Publisher

WILEY
DOI: 10.1111/jmp.12298

Keywords

CD4; fat; HIV; inflammation; RNA

Funding

  1. Henry M. Jackson Foundation for the Advancement of Military Medicine Inc. [W81XWH-11-2-0174]
  2. U.S. Department of the Army

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Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

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