Journal
DIABETES OBESITY & METABOLISM
Volume 18, Issue 2, Pages 115-124Publisher
WILEY
DOI: 10.1111/dom.12556
Keywords
accessory cells; diabetes; pancreas; transplantation; beta cell
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Funding
- Wetenschappelijk Fonds Willy Gepts (WFWG) of the UZ Brussel
- Institute for Promotion of Innovation by Science and Technology in Flanders (IWT)
- Research Foundation-Flanders (FWO)
- VUB Research Council
- European Union Sixth and Seventh Framework Program
- Belgian Federal Science Policy
- Stichting Diabetes Onderzoek Nederland
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Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes mellitus with persistent risk of glycaemic alterations and life-threatening complications. Restoration of the endogenous beta-cell mass through regeneration or transplantation offers an attractive alternative. Unfortunately, signals that drive beta-cell regeneration remain enigmatic and beta-cell replacement therapy still faces major hurdles that prevent its widespread application. Co-transplantation of accessory non-islet cells with islet cells has been shown to improve the outcome of experimental islet transplantation. This review will highlight current travails in beta-cell therapy and focuses on the potential benefits of accessory cells for islet transplantation in diabetes.
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