Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 317, Issue 6, Pages F1405-F1408Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00350.2019
Keywords
epithelial Na+ channel; fasting; insulin; glucose
Categories
Funding
- National Institutes of Health [R35-HL-135749, P01-HL-116264, T32-HL-134643]
- American Heart Association [16EIA26720006]
- Department of Veteran Affairs [I01 BX004024]
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Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na+ and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na+ handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na+ reabsorption in the kidney and the role of the epithelial Na+ channels as an important channel contributing to insulin-mediated Na+ reclamation.
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