Journal
ISCIENCE
Volume 21, Issue -, Pages 549-+Publisher
CELL PRESS
DOI: 10.1016/j.isci.2019.10.050
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Funding
- National Natural Science Foundation of China [81972629, 81972746, 8197111486]
- National New Drug Creation Special Project of China [2018ZX09736-005]
- Tianjin Science and Technology Project [18PTSYJC00060]
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Multi-targeted kinase inhibitors, such as sorafenib, have been used in various malignancies, but their efficacy in clinical applications varies among individuals and lacks pretherapeutic prediction measures. We applied the concept of dick chemistry to pathological staining and established a drug-loaded probe staining assay. We stained the cells and different types of pathological sections and demonstrated that the assay was reliable. We further verified in cells, cell-derived xenograft model, and clinical level that the staining intensity of the probe could reflect drug sensitivity. The stained samples from 300 patients who suffered from hepatocellular carcinoma and used the sorafenib probe also indicated that staining intensity was closely related to clinical information and could be used as an independent marker without undergoing sorafenib therapy for prognosis. This assay provided new ideas for multi-target drug clinical trials, pre-medication prediction, and pathological research.
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