4.7 Article

Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Bronsted acid catalyzed cascade reactions

Journal

CHEMICAL COMMUNICATIONS
Volume 55, Issue 97, Pages 14613-14616

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc07228d

Keywords

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Funding

  1. National Science Foundation of China [21702035]
  2. GDUPS
  3. Pearl River Talents Recruitment Program of Guangdong Province [2017GC010600]
  4. Science and Technology Program of Guangzhou [201804010455]

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An efficient Bronsted acid catalyzed Friedel-Crafts alkenylation/1,6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9H-pyrrolo[1,2-a]indoles in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.

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