Journal
RSC ADVANCES
Volume 9, Issue 65, Pages 38148-38153Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra08074k
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Funding
- Vietnam National Foundation for Science and Technology Development (NAFOSTED) [104.01-2019.26]
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A mild and highly efficient reaction for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetically supported Lewis acidic deep eutectic solvent on magnetic nanoparticles (LADES@MNP) has been developed via one-pot multicomponent processes under solvent-free sonication. These reactions have good to excellent yields, mild conditions, and work-up simplicity. This method represents a new method for the preparation of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles. More importantly, LADES@MNP can be easily recovered by magnetic separation and reused five times without significant loss of catalytic activity.
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