Journal
JOURNAL OF MATERIALS SCIENCE
Volume 52, Issue 15, Pages 8761-8771Publisher
SPRINGER
DOI: 10.1007/s10853-017-0787-1
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Funding
- EU H2020-NMP-PILOTS programme [685872]
- European Research Council (Advanced Grant VERDI)
- Spanish MINECO [CSO2010-11384-E, MAT2015-64831-R]
- MINECO, Spain [BES-2013-064182]
- European Research Council (ERC) [694160]
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Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into consideration. In this paper, we review the main factors that govern the mesoporous silica dissolution in physiological environments. We also provide the necessary knowledge to researchers in the area for tuning the dissolution rate of those matrices, so the degradation could be controlled and the material behaviour optimised.
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