Journal
DIABETES & VASCULAR DISEASE RESEARCH
Volume 12, Issue 5, Pages 352-358Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1479164115585298
Keywords
Dapagliflozin; sodium-glucose co-transporter 2 inhibitor; hypertension; blood pressure; type 2 diabetes
Funding
- AstraZeneca
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The effect of dapagliflozin on blood pressure was evaluated in non-hypertensive (<140mmHg) and hypertensive (>= 140mmHg) patients with type 2 diabetes mellitus. Data were pooled from 13 placebo-controlled studies. Patients received dapagliflozin 10mg/day (n=2360) or placebo (n=2295) for up to 24weeks. Dapagliflozin was associated with placebo-subtracted changes from baseline in systolic and diastolic blood pressures of -3.6 and -1.2mmHg, respectively, in hypertensive patients and -2.6 and -1.2mmHg, respectively, in non-hypertensive patients. At 24weeks, a similar proportion of patients experienced measured orthostatic reactions with dapagliflozin versus placebo in hypertensive (6.1% and 6.6%, respectively) and non-hypertensive (4.0% and 4.2%) patients. No clinically relevant difference was observed between dapagliflozin and placebo in heart rate. In conclusion, dapagliflozin 10mg induces a modest reduction in blood pressure compared with placebo in patients with diabetes with a low risk of orthostatic reactions, regardless of baseline blood pressure.
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