4.6 Review

Cancer nanomedicine: focus on recent developments and self-assembled peptide nanocarriers

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 7, Issue 48, Pages 7639-7655

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb01842e

Keywords

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Funding

  1. National Natural Science Foundation of China [81760638, 81572978]
  2. Natural Science Foundation of Xinjiang Province [2017D01C200]
  3. National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX10301402]
  4. International Cooperation and Exchange of the National Natural Science Foundation of China [51820105004]
  5. Science and Technology Program of Guangzhou [201707010094]
  6. Guangdong Innovative and Entrepreneurial Research Team Program [2013S086, 2016ZT06S029]
  7. Science and Technology Planning Project of Shenzhen [JCYJ20170307141438157]

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The applications of nanoparticulate drug delivery have received abundant interest in the field of cancer diagnosis and treatment. By virtue of their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine has spanned multitudes of drug delivery systems that possess high tumor targeting ability, sensitivity towards tumor microenvironments and improved efficacy. Various nanocarriers have been developed and approved for anti-tumor drug targeting. These nanocarriers, i.e., liposomes, micelles, nanotubes, dendrimers and peptides, offer a wide range of advantages, such as high selectivity, multi-functionality, specificity, biocompatibility and precise control of drug release. Nanomedicines based on self-assembled peptide carrier systems have been developed in recent years for cancer targeting. Self-assembled peptides have tremendous properties of forming targeted drug delivery vehicles such as nanohydrogels with unique features and functionality. In this review article, we discuss some developments in cancer nanomedicine. We present a diverse range of nanotargeted drug-delivery systems.

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