Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 427, Issue -, Pages 81-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2016.10.100
Keywords
Magnetic microrods; Biofilm; Noncontact manipulation; Infectious disease; Aspergillus
Funding
- Maryland NanoCenter
- FabLab
- AIMLab
- Georgetown Nanoscience and Microtechnology Lab
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Biofilms are a common and persistent cause of numerous illnesses. Compared to planktonic microbes, biofilm residing cells often demonstrate significant resistance to antimicrobial agents. Thus, methods for dislodging cells from the biofilm may increase the antimicrobial susceptibility of such cells, and serve as a mechanical means of increasing antimicrobial efficacy. Using Aspergillus fumigatus as a model microbe, we magnetically rotate microrods in and around biofilm. We show that such rods can improve the efficacy of antimicrobial Amphotericin B treatments in vitro. This work represents a first step in using kinetic magnetic particle therapy for disrupting fungal biofilms.
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