Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 100, Pages 15145-15148Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08463k
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Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions [19KJB150030, 19KJB150031]
- open research fund of Jiangsu Key Laboratory for Biosensors [51204080]
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A lipase-triggered drug release nanoplatform (PGL-DPP-FLU NPs) for multi-modal antifungal therapy is developed. The lipases secreted by C. albicans can accelerate FLU release. The ROS and heat produced by PGL-DPP-FLU NPs make C. albicans more vulnerable to FLU, thereby PGL-DPP-FLU NPs exhibit high performance for combating azole-resistant C. albicans biofilms and wound infection.
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