Journal
CHEMICAL COMMUNICATIONS
Volume 55, Issue 100, Pages 15133-15136Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08503c
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future Planning [2019R1H1A2079928]
- Ministry of Trade, Industry & Energy (MOTIE, Korea) [10076343]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10076343] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2019R1H1A2079928] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Herein we report the development of an efficient cellular system for the in vivo biosynthesis of Tyr-analogs and their concurrent incorporation into target proteins by the residue-specific approach. This system makes use of common phenol derivatives and the tyrosine phenol lyase machinery to create various tyrosine analogues that impart desired properties on the target proteins. Biosynthesized 2-fluorotyrosine was incorporated into three industrially important enzymes which resulted in enhanced thermostability.
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