Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 427, Issue -, Pages 156-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2016.11.003
Keywords
Magnetic particle imaging; Magnetic nanoparticles; Brownian and Neel relaxation
Funding
- European Commission Framework Programme 7 under the NanoMag project [604448]
- German Research Foundation DFG [LU800/5-1, SPP1681, SCHI383/2-1]
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Magnetic particle imaging (MPI) is an emerging medical imaging modality based on the non-linear response of magnetic nanoparticles to an exciting magnetic field. MPI has been recognized as a fast imaging technique with high spatial resolution in the mm range. For some applications of MPI, especially in the field of functional imaging, the determination of the particle mobility (Brownian rotation) is of great interest, as it enables binding detection in MPI. It also enables quantitative imaging in the presence of Brownian-dominated particles, which is otherwise implausible. Discrimination of different particle responses in MPI is possible via the joint reconstruction approach. In this contribution, we propose a dual-frequency acquisition scheme to enhance sensitivity and contrast in the detection of different particle mobilities compared to a standard single-frequency MPI protocol. The method takes advantage of the fact, that the magnetization response of the tracer is strongly frequency-dependent, i.e. for low excitation frequencies a stronger Brownian contribution is observed.
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