Journal
EUROPEAN CARDIOLOGY REVIEW
Volume 14, Issue 2, Pages 117-122Publisher
RADCLIFFE CARDIOLOGY
DOI: 10.15420/ecr.2019.17.2
Keywords
Inflammation; curcumin; lifestyle-related diseases; cardiovascular risk factor; natural product
Categories
Funding
- National Hospital Organization
Ask authors/readers for more resources
Chronic inflammation plays a significant role in lifestyle-related diseases, such as cardiovascular diseases and obesity/impaired glucose tolerance. Curcumin is a natural extract that possesses numerous physiological properties, as indicated by its anti-inflammatory action. The mechanisms underlying these effects include the inhibition of nuclear factor-kappaB and Toll-like receptor 4-dependent signalling pathways and the activation of a peroxisome proliferator-activated receptor-gamma pathway. However, the bioavailability of curcumin is very low in humans. To resolve this issue, several drug delivery systems have been developed and a number of clinical trials have reported beneficial effects of curcumin in the management of inflammation-related diseases. It is expected that evidence regarding the clinical application of curcumin in lifestyle-related diseases associated with chronic inflammation will accumulate over time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available