Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 274, Issue -, Pages 65-72Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2016.11.008
Keywords
Hyperpolarized water; Dissolution-DNP; Hyperpolarization
Funding
- Danish Research Council [12-127232]
- Danish National Research Foundation [DNRF124]
- Lundbeck Foundation [R95-2012-10581] Funding Source: researchfish
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We demonstrate a method for the preparation of hyperpolarized water by dissolution Dynamic Nuclear Polarization at high magnetic field. Protons were polarized at 6.7T and 1.1 K to >70% with frequency modulated microwave irradiation at 188G Hz .97.2 +/- 0.7% of the radical was extracted from the sample in the dissolution in a two-phase system. 16 +/- 1 mL of 5.0 M H-1 in D2O with a polarization of 13.0 +/- 0.9% in the liquid state was obtained, corresponding to an enhancement factor of 4000 300 compared to the thermal equilibrium at 9.4 T and 293 K. A longitudinal relaxation time constant of 16 +/- 1 s was measured. The sample was polarized and dissolved in a fluid path compatible with clinical polarizers. The volume of hyperpolarized water produced by this method enables angiography and perfusion measurements in large animals, as well as NMR experiments for studies of e.g. proton exchange and polarization transfer to other nuclei. (C) 2016 Elsevier Inc. All rights reserved.
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