Journal
NANOSCALE
Volume 11, Issue 44, Pages 21030-21045Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nr06558j
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Funding
- National Natural Science Foundation of China [51572258, 51872263]
- Zhejiang Provincial Natural Science Foundation [LZ19E020001]
- Zhejiang Provincial Ten Thousands Talents Program [2018R52005]
- Jilin Provincial Natural Science Foundation [2018010119JC]
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As a new kind of porous material, zeolitic imidazolate frameworks (ZIF-8) are built from zinc ions and 2-methylimidazolate and possess unique merits including high porosity, good structural regularity and tunability, adjustable surface functionality and intrinsic pH induced biodegradability. These advantages endow ZIF-8 with multiple functionalities and stimuli-responsive controlled release of loaded payloads by endogenous or exogenous means. In this review, we will summarize the recent advancement of ZIF-8 as nanocarriers for the loading of various molecules including chemotherapeutic drugs, photosensitizers, photothermal agents, and proteins to fabricate multifunctional nanocomposites for synergistic cancer therapy. In addition, the challenges and future developments in this area will be highlighted.
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