Journal
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
Volume 54, Issue 12, Pages 902-907Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10601325.2017.1381852
Keywords
ADMA; purification; amino acid; nanoparticle; acrylic acid; isolation
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Funding
- Hittite University Scientific Research Projects Coordination Unit [ODMYO19001.15.001]
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Separation and purification of asymmetric dimethylarginine (ADMA) molecule, which is an important biomolecule in terms of cardiovascular diseases, is of great importance. Among the methods, the adsorption technique is of considerable demand, and as an adsorbent, the nanoparticles are widely used. In this study, an ADMA isolation was performed via a novel method. Therefore, ADMA adsorption was achieved using a poly (2-hydroxyethyl methacrylate-acrylic acid) (poly(HEMA-AA)) nanoparticles. The change in the adsorption capacity was investigated in terms of changing interaction time, initial ADMA concentration, stirring rate, temperature and ionic strength. The functional group on the polymeric nanoparticles was characterized using Fourier Transform Infrared Spectroscopy (FT-IR); the surface morphology was determined via scanning electron microscopy (SEM), transient electron microscopy (TEM) and surface area (BET) analyzes. The Elisa Spectrophotometer was used for the quantitative analysis of the ADMA molecule. The adsorption capacity of the nanoparticles was determined as 23.76mg/g. The adsorption process was characterized according to the isotherm calculation.
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