Journal
RSC ADVANCES
Volume 9, Issue 69, Pages 40336-40339Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra08256e
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Funding
- Wellcome Trust [098256/Z/12/Z]
- Wellcome Trust [098256/Z/12/Z] Funding Source: Wellcome Trust
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The unusual alpha-amino, beta-hydroxy acid MeBmt is a key structural feature of cyclosporin A, an important naturally occurring immunosuppressant and antiviral agent. We present a convergent synthesis of MeBmt which relies on new aspects of dynamic kinetic resolution (DKR) to establish simultaneously the chirality at C(2) and C(3). We also show that this route is applicable to the synthesis of other derivatives.
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