4.6 Article

The Ag-promoted α-C-H arylation of alcohols

Journal

RSC ADVANCES
Volume 9, Issue 71, Pages 41847-41850

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ra09954a

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Funding

  1. Natural Science Foundation [31972850]
  2. Shandong Provincial Natural Science Foundation [ZR2016HM44, ZR2016BQ31, ZR2016JL009, ZR2017ZC0529]
  3. Shandong Key Research Program [2017GSF218061]
  4. University of Jinan

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We herein report the functionalization of alpha-C-H in alcohols through cross-dehydrogenative coupling reactions. Selectfluor was used as a mild oxidant. In situ-generated HF participated in the reaction and no external strong acid was necessary. A variety of heteroaryl-substituted alcohols were achieved with good yields and with good functional group tolerance.

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