Journal
JOURNAL OF LIPID RESEARCH
Volume 58, Issue 6, Pages 1036-1043Publisher
ELSEVIER
DOI: 10.1194/jlr.R075507
Keywords
apolipoproteins; Alzheimer's disease; endocytosis; lipoprotein receptors; cell signaling; neurons; apolipoprotein E; very low density lipoprotein receptor; apolipoprotein E receptor 2
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Funding
- National Institutes of Health [F30-AG047799, HL063762, NS093382, AG053391]
- Consortium for Frontotemporal Dementia Research
- BrightFocus Foundation
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The LDL receptor (LDLR) family has long been studied for its role in cholesterol transport and metabolism; however, the identification of ApoE4, an LDLR ligand, as a genetic risk factor for late-onset Alzheimer's disease has focused attention on the role this receptor family plays in the CNS. Surprisingly, it was discovered that two LDLR family members, ApoE receptor 2 (Apoer2) and VLDL receptor (Vldlr), play key roles in brain development and adult synaptic plasticity, primarily by mediating Reelin signaling. This review focuses on Apoer2 and Vldlr signaling in the CNS and its role in human disease.
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