Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 17, Issue -, Pages 854-861Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2019.06.005
Keywords
Cancer; CIN; TRIP13; Oncogenes
Funding
- National Natural Science Foundation of China [81770220, 81600177, 81670200]
- 2016 outstanding youth fund of Jiangsu Province [BK20160048]
- Natural Science Foundation of Jiangsu Province [BK20161041]
- National key research and development program-precision medicine subprogram [2016YFC0905900]
- Priority Academic Program Development of Jiangsu Higher Education Institutions for Chinese Medicine
Ask authors/readers for more resources
Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) plays a key role in regulating mitotic processes, including spindle assembly checkpoint and DNA repair pathways, which may account for Chromosome instability (CIN). As CIN is a predominant hallmark of cancer, TRIP13 may act as a tumor susceptibility locus.Amplification of TRIP13 has been observed in various human cancers and implicated in several aspects of malignant transformation, including cancer cell proliferation, drug resistance and tumor progression. Here, we discussed the functional significance of TRIP13 in cell progression, highlighted the recent findings on the aberrant expression in human cancers and emphasized its significance for the therapeutic potential. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
